Assay Detail
Toxicity
CHEMBL5325810
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Cytotoxicity against HEK293-T-REx cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293-T-REx |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design of Cytochrome P450 1B1 Inhibitors <i>via</i> a Scaffold-Hopping Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.23 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405212 | — | — | 1 | 6.75 |
| CHEMBL46909 | — | — | 1 | 5.89 |
| CHEMBL5406721 | — | — | 1 | 5.79 |
| CHEMBL5406218 | — | — | 1 | 5.47 |
| CHEMBL5395150 | — | — | 1 | 5.38 |
| CHEMBL5401832 | — | — | 1 | 5.00 |
| CHEMBL5396198 | — | — | 1 | 5.00 |
| CHEMBL5406117 | — | — | 1 | 5.00 |
| CHEMBL5438759 | — | — | 1 | 5.00 |
| CHEMBL5418617 | — | — | 1 | 5.00 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 4.83 |
| CHEMBL5406710 | — | — | 1 | 4.57 |
| CHEMBL5401046 | — | — | 1 | 4.29 |
| CHEMBL5429178 | — | — | 1 | - |
| CHEMBL5412548 | — | — | 1 | - |
| CHEMBL380753 | — | — | 1 | - |
| CHEMBL5394220 | — | — | 1 | - |
| CHEMBL5426573 | — | — | 1 | - |
| CHEMBL5425709 | — | — | 1 | - |
| CHEMBL5406156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405212 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL46909 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5406721 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5406218 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5395150 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL5401832 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5396198 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5406117 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5438759 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5418617 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL5406710 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL5401046 | — | IC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL5429178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412548 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL380753 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5394220 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426573 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425709 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5406156 | — | IC50 | > | 10000.0 | nM | - |