Assay Detail
Functional
CHEMBL5325877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.26 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL5418168 | — | — | 1 | 8.72 |
| CHEMBL5407825 | — | — | 1 | 8.51 |
| CHEMBL5421557 | — | — | 1 | 8.36 |
| CHEMBL5413209 | — | — | 1 | 7.63 |
| CHEMBL5407334 | — | — | 1 | 7.50 |
| CHEMBL5432308 | — | — | 1 | 7.41 |
| CHEMBL387187 | — | — | 1 | 7.34 |
| CHEMBL5400261 | — | — | 1 | 7.31 |
| CHEMBL5412110 | — | — | 1 | 7.19 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.17 |
| CHEMBL5412150 | — | — | 1 | 6.98 |
| CHEMBL5428583 | — | — | 1 | 6.97 |
| CHEMBL5438883 | — | — | 1 | 6.91 |
| CHEMBL5426650 | — | — | 1 | 6.81 |
| CHEMBL5439492 | — | — | 1 | 6.45 |
| CHEMBL5425551 | — | — | 1 | 6.36 |
| CHEMBL5439846 | — | — | 1 | 6.25 |
| CHEMBL5409008 | — | — | 1 | 6.21 |
| CHEMBL5407641 | — | — | 1 | 6.19 |
| CHEMBL5423310 | — | — | 1 | - |
| CHEMBL5422615 | — | — | 1 | - |
| CHEMBL5403676 | — | — | 1 | - |
| CHEMBL5416236 | — | — | 1 | - |
| CHEMBL5418955 | — | — | 1 | - |
| CHEMBL5436590 | — | — | 1 | - |
| CHEMBL5436594 | — | — | 1 | - |
| CHEMBL5429962 | — | — | 1 | - |
| CHEMBL5422511 | — | — | 1 | - |
| CHEMBL5434822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5418168 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5407825 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5421557 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5413209 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL5407334 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL5432308 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL387187 | — | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL5400261 | — | IC50 | = | 48.8 | nM | 7.31 |
| CHEMBL5412110 | — | IC50 | = | 64.9 | nM | 7.19 |
| CHEMBL107 | COLCHICINE | IC50 | = | 67.4 | nM | 7.17 |
| CHEMBL5412150 | — | IC50 | = | 105.4 | nM | 6.98 |
| CHEMBL5428583 | — | IC50 | = | 106.9 | nM | 6.97 |
| CHEMBL5438883 | — | IC50 | = | 122.1 | nM | 6.91 |
| CHEMBL5426650 | — | IC50 | = | 154.8 | nM | 6.81 |
| CHEMBL5439492 | — | IC50 | = | 355.5 | nM | 6.45 |
| CHEMBL5425551 | — | IC50 | = | 437.6 | nM | 6.36 |
| CHEMBL5439846 | — | IC50 | = | 562.7 | nM | 6.25 |
| CHEMBL5409008 | — | IC50 | = | 610.2 | nM | 6.21 |
| CHEMBL5407641 | — | IC50 | = | 644.5 | nM | 6.19 |
| CHEMBL5414350 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5396020 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5399776 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5422445 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5406164 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5419572 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5437179 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436191 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436747 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5415365 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5435087 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5412160 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5406870 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5408968 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5432008 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5438186 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5421142 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5434822 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5422511 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5429962 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436594 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436590 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5418955 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5416236 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5403676 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5422615 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5423310 | — | IC50 | > | 1000.0 | nM | - |