Assay Detail
Functional
CHEMBL5325878
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.24 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407825 | — | — | 1 | 8.49 |
| CHEMBL5421557 | — | — | 1 | 8.44 |
| CHEMBL5412160 | — | — | 1 | 8.17 |
| CHEMBL5400261 | — | — | 1 | 7.75 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.70 |
| CHEMBL5412110 | — | — | 1 | 7.65 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.47 |
| CHEMBL5412150 | — | — | 1 | 7.38 |
| CHEMBL5407334 | — | — | 1 | 7.34 |
| CHEMBL5432308 | — | — | 1 | 7.31 |
| CHEMBL5415365 | — | — | 1 | 7.28 |
| CHEMBL5413209 | — | — | 1 | 7.21 |
| CHEMBL5428583 | — | — | 1 | 7.18 |
| CHEMBL387187 | — | — | 1 | 7.08 |
| CHEMBL5429962 | — | — | 1 | 6.92 |
| CHEMBL5425551 | — | — | 1 | 6.89 |
| CHEMBL5439846 | — | — | 1 | 6.46 |
| CHEMBL5439492 | — | — | 1 | 6.40 |
| CHEMBL5426650 | — | — | 1 | 6.32 |
| CHEMBL5414350 | — | — | 1 | 6.30 |
| CHEMBL5418168 | — | — | 1 | 6.21 |
| CHEMBL5436594 | — | — | 1 | - |
| CHEMBL5438883 | — | — | 1 | - |
| CHEMBL5418955 | — | — | 1 | - |
| CHEMBL5421142 | — | — | 1 | - |
| CHEMBL5422511 | — | — | 1 | - |
| CHEMBL5438186 | — | — | 1 | - |
| CHEMBL5432008 | — | — | 1 | - |
| CHEMBL5416236 | — | — | 1 | - |
| CHEMBL5403676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407825 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5421557 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5412160 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5400261 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL5412110 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL107 | COLCHICINE | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL5412150 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL5407334 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL5432308 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL5415365 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL5413209 | — | IC50 | = | 62.2 | nM | 7.21 |
| CHEMBL5428583 | — | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL387187 | — | IC50 | = | 83.4 | nM | 7.08 |
| CHEMBL5429962 | — | IC50 | = | 120.5 | nM | 6.92 |
| CHEMBL5425551 | — | IC50 | = | 130.1 | nM | 6.89 |
| CHEMBL5439846 | — | IC50 | = | 349.1 | nM | 6.46 |
| CHEMBL5439492 | — | IC50 | = | 396.7 | nM | 6.40 |
| CHEMBL5426650 | — | IC50 | = | 475.3 | nM | 6.32 |
| CHEMBL5414350 | — | IC50 | = | 498.8 | nM | 6.30 |
| CHEMBL5418168 | — | IC50 | = | 613.4 | nM | 6.21 |
| CHEMBL5422615 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436590 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5435087 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436747 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5419572 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5422445 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5399776 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5396020 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5406870 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5406164 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5437179 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436191 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5407641 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5423310 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5408968 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5409008 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5434822 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5403676 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5416236 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5432008 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5438186 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5422511 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5421142 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5418955 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5438883 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5436594 | — | IC50 | > | 1000.0 | nM | - |