Assay Detail
Binding
CHEMBL5326122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Covalent inhibition of p97 (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by Biomol Green Reagent based microplate reader analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transitional endoplasmic reticulum ATPase (CHEMBL1075145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl) phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.66 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420815 | — | — | 1 | 9.46 |
| CHEMBL5414874 | — | — | 1 | 9.44 |
| CHEMBL5423427 | — | — | 1 | 8.87 |
| CHEMBL5431792 | — | — | 1 | 8.44 |
| CHEMBL5420985 | — | — | 1 | 8.36 |
| CHEMBL5402707 | — | — | 1 | 8.14 |
| CHEMBL5428666 | — | — | 1 | 8.13 |
| CHEMBL5430557 | — | — | 1 | 8.09 |
| CHEMBL5396390 | — | — | 1 | 8.08 |
| CHEMBL5405131 | — | — | 1 | 8.07 |
| CHEMBL5412755 | — | — | 1 | 7.97 |
| CHEMBL5423222 | — | — | 1 | 7.92 |
| CHEMBL5400122 | — | — | 1 | 7.89 |
| CHEMBL5402810 | — | — | 1 | 7.86 |
| CHEMBL5415375 | — | — | 1 | 7.85 |
| CHEMBL5417192 | — | — | 1 | 7.83 |
| CHEMBL5439553 | — | — | 1 | 7.81 |
| CHEMBL5410189 | — | — | 1 | 7.80 |
| CHEMBL5428726 | — | — | 1 | 7.78 |
| CHEMBL5410787 | — | — | 1 | 7.75 |
| CHEMBL5401866 | — | — | 1 | 7.73 |
| CHEMBL5422395 | — | — | 1 | 7.72 |
| CHEMBL5433632 | — | — | 1 | 7.71 |
| CHEMBL5425652 | — | — | 1 | 7.64 |
| CHEMBL5430775 | — | — | 1 | 7.59 |
| CHEMBL5427428 | — | — | 1 | 7.54 |
| CHEMBL5436721 | — | — | 1 | 7.49 |
| CHEMBL5435725 | — | — | 1 | 7.37 |
| CHEMBL5415803 | — | — | 1 | 7.25 |
| CHEMBL3747513 | CB-5083 | 1.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420815 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5414874 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL5423427 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL5431792 | — | IC50 | = | 3.65 | nM | 8.44 |
| CHEMBL5420985 | — | IC50 | = | 4.39 | nM | 8.36 |
| CHEMBL5402707 | — | IC50 | = | 7.19 | nM | 8.14 |
| CHEMBL5428666 | — | IC50 | = | 7.36 | nM | 8.13 |
| CHEMBL5430557 | — | IC50 | = | 8.07 | nM | 8.09 |
| CHEMBL5396390 | — | IC50 | = | 8.39 | nM | 8.08 |
| CHEMBL5405131 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5412755 | — | IC50 | = | 10.68 | nM | 7.97 |
| CHEMBL5423222 | — | IC50 | = | 12.09 | nM | 7.92 |
| CHEMBL5400122 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL5402810 | — | IC50 | = | 13.86 | nM | 7.86 |
| CHEMBL5415375 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5417192 | — | IC50 | = | 14.61 | nM | 7.83 |
| CHEMBL5439553 | — | IC50 | = | 15.52 | nM | 7.81 |
| CHEMBL5410189 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL5428726 | — | IC50 | = | 16.64 | nM | 7.78 |
| CHEMBL5410787 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL5401866 | — | IC50 | = | 18.57 | nM | 7.73 |
| CHEMBL5422395 | — | IC50 | = | 19.24 | nM | 7.72 |
| CHEMBL5433632 | — | IC50 | = | 19.67 | nM | 7.71 |
| CHEMBL5425652 | — | IC50 | = | 22.78 | nM | 7.64 |
| CHEMBL5430775 | — | IC50 | = | 25.63 | nM | 7.59 |
| CHEMBL5427428 | — | IC50 | = | 28.65 | nM | 7.54 |
| CHEMBL5436721 | — | IC50 | = | 32.27 | nM | 7.49 |
| CHEMBL5435725 | — | IC50 | = | 42.39 | nM | 7.37 |
| CHEMBL5415803 | — | IC50 | = | 55.64 | nM | 7.25 |
| CHEMBL3747513 | CB-5083 | IC50 | = | 81.08 | nM | 7.09 |
| CHEMBL2311578 | — | IC50 | = | 123.3 | nM | 6.91 |
| CHEMBL5412356 | — | IC50 | = | 172.2 | nM | 6.76 |
| CHEMBL5410404 | — | IC50 | = | 283.27 | nM | 6.55 |
| CHEMBL5394493 | — | IC50 | = | 363.07 | nM | 6.44 |
| CHEMBL5428972 | — | IC50 | = | 3251.84 | nM | 5.49 |
| CHEMBL5435760 | — | IC50 | = | 9401.33 | nM | 5.03 |
| CHEMBL5427687 | — | IC50 | - | — | - |