Assay Detail
Functional
CHEMBL5326136
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Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 infected in Red blood cell assessed as growth inhibition measured after 72 hrs by LDH assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Red blood cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 6.53 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.48 |
| CHEMBL4435950 | — | — | 1 | 7.20 |
| CHEMBL5420788 | — | — | 1 | 6.99 |
| CHEMBL5397232 | — | — | 1 | 6.94 |
| CHEMBL5420410 | — | — | 1 | 6.87 |
| CHEMBL5417578 | — | — | 1 | 6.84 |
| CHEMBL5408633 | — | — | 1 | 6.84 |
| CHEMBL5405530 | — | — | 1 | 6.81 |
| CHEMBL5394813 | — | — | 1 | 6.81 |
| CHEMBL5410995 | — | — | 1 | 6.81 |
| CHEMBL5423988 | — | — | 1 | 6.77 |
| CHEMBL5426789 | — | — | 1 | 6.76 |
| CHEMBL5413443 | — | — | 1 | 6.76 |
| CHEMBL5413124 | — | — | 1 | 6.70 |
| CHEMBL5432646 | — | — | 1 | 6.69 |
| CHEMBL5413980 | — | — | 1 | 6.66 |
| CHEMBL5435678 | — | — | 1 | 6.66 |
| CHEMBL5437531 | — | — | 1 | 6.64 |
| CHEMBL5432749 | — | — | 1 | 6.60 |
| CHEMBL5400810 | — | — | 1 | 6.60 |
| CHEMBL5430122 | — | — | 1 | 6.54 |
| CHEMBL5436252 | — | — | 1 | 6.54 |
| CHEMBL3765455 | — | — | 1 | 6.47 |
| CHEMBL5428536 | — | — | 1 | 6.46 |
| CHEMBL5423039 | — | — | 1 | 6.43 |
| CHEMBL5412809 | — | — | 1 | 6.37 |
| CHEMBL5430328 | — | — | 1 | 6.34 |
| CHEMBL5401610 | — | — | 1 | 6.32 |
| CHEMBL5411247 | — | — | 1 | 6.22 |
| CHEMBL5423346 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4435950 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5420788 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5397232 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5420410 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5417578 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5408633 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5405530 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5394813 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5410995 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5423988 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5426789 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5413443 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5413124 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5432646 | — | EC50 | = | 205.0 | nM | 6.69 |
| CHEMBL5413980 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5435678 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5437531 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5400810 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5432749 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5430122 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL5436252 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL3765455 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5428536 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5423039 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5412809 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5430328 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5401610 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5411247 | — | EC50 | = | 605.0 | nM | 6.22 |
| CHEMBL5423346 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5398883 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5438408 | — | EC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5393875 | — | EC50 | = | 675.0 | nM | 6.17 |
| CHEMBL5433887 | — | EC50 | = | 725.0 | nM | 6.14 |
| CHEMBL5402065 | — | EC50 | = | 825.0 | nM | 6.08 |
| CHEMBL5431689 | — | EC50 | = | 1195.0 | nM | 5.92 |
| CHEMBL5436122 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5428321 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5435464 | — | EC50 | = | 1800.0 | nM | 5.75 |