Assay Detail
Toxicity
CHEMBL5326435
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Cytotoxicity against human MCF-10A cells incubated for 72 hrs by CCK8 assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.57 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426251 | — | — | 1 | 4.86 |
| CHEMBL5405944 | — | — | 1 | 4.77 |
| CHEMBL5423258 | — | — | 1 | 4.76 |
| CHEMBL5437007 | — | — | 1 | 4.75 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 4.67 |
| CHEMBL5396802 | — | — | 1 | 4.66 |
| CHEMBL5426947 | — | — | 1 | 4.63 |
| CHEMBL5394546 | — | — | 1 | 4.60 |
| CHEMBL5404063 | — | — | 1 | 4.58 |
| CHEMBL5414659 | — | — | 1 | 4.54 |
| CHEMBL5433442 | — | — | 1 | 4.36 |
| CHEMBL5410004 | — | — | 1 | 4.29 |
| CHEMBL5398724 | — | — | 1 | 4.29 |
| CHEMBL4800654 | — | — | 1 | 4.24 |
| CHEMBL5398866 | — | — | 1 | - |
| CHEMBL5432102 | — | — | 1 | - |
| CHEMBL5394879 | — | — | 1 | - |
| CHEMBL5423408 | — | — | 1 | - |
| CHEMBL5428681 | — | — | 1 | - |
| CHEMBL5423781 | — | — | 1 | - |
| CHEMBL5418690 | — | — | 1 | - |
| CHEMBL5414261 | — | — | 1 | - |
| CHEMBL5394007 | — | — | 1 | - |
| CHEMBL5419649 | — | — | 1 | - |
| CHEMBL5436713 | — | — | 1 | - |
| CHEMBL5424929 | — | — | 1 | - |
| CHEMBL5403080 | — | — | 1 | - |
| CHEMBL5433532 | — | — | 1 | - |
| CHEMBL5402392 | — | — | 1 | - |
| CHEMBL5413340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426251 | — | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL5405944 | — | IC50 | = | 16890.0 | nM | 4.77 |
| CHEMBL5423258 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5437007 | — | IC50 | = | 17980.0 | nM | 4.75 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL5396802 | — | IC50 | = | 21720.0 | nM | 4.66 |
| CHEMBL5426947 | — | IC50 | = | 23350.0 | nM | 4.63 |
| CHEMBL5394546 | — | IC50 | = | 25240.0 | nM | 4.60 |
| CHEMBL5404063 | — | IC50 | = | 26330.0 | nM | 4.58 |
| CHEMBL5414659 | — | IC50 | = | 28570.0 | nM | 4.54 |
| CHEMBL5433442 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL5410004 | — | IC50 | = | 51250.0 | nM | 4.29 |
| CHEMBL5398724 | — | IC50 | = | 50880.0 | nM | 4.29 |
| CHEMBL4800654 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5403786 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5436925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5412790 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5411799 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5400803 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5420394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5417452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5422315 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5401146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5421409 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5414572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5427513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5400203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5399056 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5404699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1444 | LETROZOLE | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5407335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5414261 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5413340 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5402392 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5433532 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5403080 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5436713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5419649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5394007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5408038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418690 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5423781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5428681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5423408 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5394879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5432102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5398866 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1358 | FULVESTRANT | IC50 | > | 100000.0 | nM | - |