Assay Detail
Functional
CHEMBL5326437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Tamoxifen-resistant LCC2 cell incubated for 72 hrs by CCK8 assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Tamoxifen-resistant LCC2 cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.86 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398724 | — | — | 1 | 5.37 |
| CHEMBL5396802 | — | — | 1 | 5.36 |
| CHEMBL5421409 | — | — | 1 | 5.36 |
| CHEMBL5427513 | — | — | 1 | 5.29 |
| CHEMBL5404063 | — | — | 1 | 5.05 |
| CHEMBL5426947 | — | — | 1 | 4.99 |
| CHEMBL5423258 | — | — | 1 | 4.95 |
| CHEMBL5420394 | — | — | 1 | 4.95 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 4.94 |
| CHEMBL5403786 | — | — | 1 | 4.94 |
| CHEMBL5413340 | — | — | 1 | 4.94 |
| CHEMBL5405944 | — | — | 1 | 4.93 |
| CHEMBL5400203 | — | — | 1 | 4.92 |
| CHEMBL5437007 | — | — | 1 | 4.89 |
| CHEMBL5426251 | — | — | 1 | 4.80 |
| CHEMBL5419649 | — | — | 1 | 4.74 |
| CHEMBL5399056 | — | — | 1 | 4.74 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 4.74 |
| CHEMBL4800654 | — | — | 1 | 4.70 |
| CHEMBL5394546 | — | — | 1 | 4.63 |
| CHEMBL5414261 | — | — | 1 | 4.62 |
| CHEMBL5414659 | — | — | 1 | 4.61 |
| CHEMBL5407335 | — | — | 1 | 4.61 |
| CHEMBL5433532 | — | — | 1 | 4.58 |
| CHEMBL5412790 | — | — | 1 | 4.58 |
| CHEMBL5403080 | — | — | 1 | 4.57 |
| CHEMBL5408038 | — | — | 1 | 4.53 |
| CHEMBL5394007 | — | — | 1 | - |
| CHEMBL5401146 | — | — | 1 | - |
| CHEMBL5418690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398724 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL5396802 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5421409 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL5427513 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL5404063 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL5426947 | — | IC50 | = | 10310.0 | nM | 4.99 |
| CHEMBL5423258 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5420394 | — | IC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 11520.0 | nM | 4.94 |
| CHEMBL5413340 | — | IC50 | = | 11430.0 | nM | 4.94 |
| CHEMBL5403786 | — | IC50 | = | 11430.0 | nM | 4.94 |
| CHEMBL5405944 | — | IC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL5400203 | — | IC50 | = | 11990.0 | nM | 4.92 |
| CHEMBL5437007 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL5426251 | — | IC50 | = | 15860.0 | nM | 4.80 |
| CHEMBL5419649 | — | IC50 | = | 18170.0 | nM | 4.74 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 18330.0 | nM | 4.74 |
| CHEMBL5399056 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL4800654 | — | IC50 | = | 20190.0 | nM | 4.70 |
| CHEMBL5394546 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL5414261 | — | IC50 | = | 24190.0 | nM | 4.62 |
| CHEMBL5414659 | — | IC50 | = | 24820.0 | nM | 4.61 |
| CHEMBL5407335 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL5433532 | — | IC50 | = | 26190.0 | nM | 4.58 |
| CHEMBL5412790 | — | IC50 | = | 26190.0 | nM | 4.58 |
| CHEMBL5403080 | — | IC50 | = | 27140.0 | nM | 4.57 |
| CHEMBL5408038 | — | IC50 | = | 29850.0 | nM | 4.53 |
| CHEMBL5433442 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5410004 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5411799 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5435743 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5414572 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5436925 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5422315 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5424929 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5436713 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5404699 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5400803 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5417452 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5423781 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5428681 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5426175 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5402392 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5423408 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5394879 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5432102 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5398866 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5418690 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5401146 | — | IC50 | > | 31600.0 | nM | - |
| CHEMBL5394007 | — | IC50 | > | 31600.0 | nM | - |