Assay Detail

CHEMBL5326476

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Binding

Inhibition of PP2A (unknown origin) phosphatase domain

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery.

Zhang H, Zhang Q, Tu J, You Q, Wang L.
Eur J Med Chem (2023) 254 : 115350 -115350
PubMed 37054560 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.81	8.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL17377	FOSTRIECIN	2.0	1	8.82
CHEMBL48449	CANTHARIDIN	4.0	1	6.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL17377	FOSTRIECIN	IC50	=	1.5	nM	8.82
CHEMBL48449	CANTHARIDIN	IC50	=	160.0	nM	6.80