Assay Detail
Binding
CHEMBL5326482
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Inhibition of PPP5C (unknown origin) phosphatase domain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 5 (CHEMBL3425389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 9.00 |
| CHEMBL5405890 | — | — | 1 | 6.16 |
| CHEMBL5421006 | — | — | 1 | 6.00 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 6.00 |
| CHEMBL17377 | FOSTRIECIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5405890 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5421006 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL17377 | FOSTRIECIN | IC50 | > | 1.0 | 10^3nM | - |