Assay Detail
Functional
CHEMBL5326951
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Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.38 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435925 | — | — | 1 | 6.60 |
| CHEMBL5433364 | — | — | 1 | 6.43 |
| CHEMBL5434546 | — | — | 1 | 6.41 |
| CHEMBL5406191 | — | — | 1 | 6.39 |
| CHEMBL5440196 | — | — | 1 | 6.32 |
| CHEMBL5440032 | — | — | 1 | 6.28 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435925 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5433364 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5434546 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5406191 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5440196 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5440032 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 570.0 | nM | 6.24 |