Assay Detail
Toxicity
CHEMBL5326953
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Cytotoxicity against human GES1 cells harboring low LSD1 expression assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | GES1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.05 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435925 | — | — | 1 | 5.06 |
| CHEMBL5434546 | — | — | 1 | 5.05 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.04 |
| CHEMBL5433364 | — | — | 1 | - |
| CHEMBL5440196 | — | — | 1 | - |
| CHEMBL5406191 | — | — | 1 | - |
| CHEMBL5440032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435925 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL5434546 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL5433364 | — | IC50 | - | — | - | |
| CHEMBL5440196 | — | IC50 | - | — | - | |
| CHEMBL5406191 | — | IC50 | - | — | - | |
| CHEMBL5440032 | — | IC50 | - | — | - |