Assay Detail
Binding
CHEMBL5326959
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Inhibition of N-terminal FLAG-tagged human recombinant MAO-B expressed in Sf9 cells preincubated for 15 mins followed by MAO substrate addition and measured after 60 mins by luminescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.16 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.16 |
| CHEMBL5435925 | — | — | 1 | - |
| CHEMBL5434546 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5435925 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5434546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |