Assay Detail
Functional
CHEMBL5327356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse Ba/F3 EGFR-Del19/T790M/C797S cells assessed as cell growth inhibition measured after 72 hrs by CellTiter-Glo luminescent assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-Del19/T790M/C797S |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of phosphoroxy quinazoline derivatives as potential EGFR<sup>T790M/C797S</sup> inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.65 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431909 | — | — | 1 | 8.05 |
| CHEMBL5418539 | — | — | 1 | 7.96 |
| CHEMBL5186680 | — | — | 1 | 7.90 |
| CHEMBL5397801 | — | — | 1 | 7.90 |
| CHEMBL5434495 | — | — | 1 | 7.82 |
| CHEMBL5436031 | — | — | 1 | 7.80 |
| CHEMBL5180388 | — | — | 1 | 7.79 |
| CHEMBL5396086 | — | — | 1 | 7.79 |
| CHEMBL5393923 | — | — | 1 | 7.75 |
| CHEMBL5422588 | — | — | 1 | 7.75 |
| CHEMBL5399653 | — | — | 1 | 7.75 |
| CHEMBL5415311 | — | — | 1 | 7.73 |
| CHEMBL5432965 | — | — | 1 | 7.71 |
| CHEMBL5416489 | — | — | 1 | 7.65 |
| CHEMBL5179357 | — | — | 1 | 7.54 |
| CHEMBL5415418 | — | — | 1 | 7.53 |
| CHEMBL5435775 | — | — | 1 | 7.39 |
| CHEMBL5425947 | — | — | 1 | 7.27 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431909 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5418539 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5186680 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5397801 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5434495 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5436031 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5180388 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5396086 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5393923 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL5422588 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL5399653 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5415311 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL5432965 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL5416489 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL5179357 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5415418 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL5435775 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5425947 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 432.7 | nM | 6.36 |