Assay Detail
Binding
CHEMBL5327390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to thyroxin binding site of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching of intrinsic tryptophan fluorescence by measuring apparent dissociation constant incubated for 60 mins by fluorescence based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.41 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 6.70 |
| CHEMBL232201 | BENZIODARONE | 4.0 | 1 | 6.39 |
| CHEMBL5422596 | — | — | 1 | 6.39 |
| CHEMBL1767079 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL232201 | BENZIODARONE | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL5422596 | — | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL1767079 | — | Kd | = | 700.0 | nM | 6.16 |