Assay Detail
Functional
CHEMBL5327465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCk-8 assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A: Design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.91 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.47 |
| CHEMBL19980 | BREFELDIN A | — | 1 | 7.36 |
| CHEMBL5420527 | — | — | 1 | 6.64 |
| CHEMBL5399866 | — | — | 1 | 6.52 |
| CHEMBL5403345 | — | — | 1 | 6.43 |
| CHEMBL5438677 | — | — | 1 | 6.11 |
| CHEMBL5398095 | — | — | 1 | 6.07 |
| CHEMBL5435512 | — | — | 1 | 6.07 |
| CHEMBL5428467 | — | — | 1 | 5.63 |
| CHEMBL5423886 | — | — | 1 | 5.46 |
| CHEMBL5401692 | — | — | 1 | 5.28 |
| CHEMBL5428463 | — | — | 1 | 5.25 |
| CHEMBL402341 | — | — | 1 | 5.19 |
| CHEMBL5406439 | — | — | 1 | 4.60 |
| CHEMBL5414388 | — | — | 1 | 4.57 |
| CHEMBL5405850 | — | — | 1 | - |
| CHEMBL5416809 | — | — | 1 | - |
| CHEMBL5402975 | — | — | 1 | - |
| CHEMBL5402464 | — | — | 1 | - |
| CHEMBL5436861 | — | — | 1 | - |
| CHEMBL5423485 | — | — | 1 | - |
| CHEMBL5395276 | — | — | 1 | - |
| CHEMBL5397013 | — | — | 1 | - |
| CHEMBL5419421 | — | — | 1 | - |
| CHEMBL5407348 | — | — | 1 | - |
| CHEMBL5394303 | — | — | 1 | - |
| CHEMBL5412475 | — | — | 1 | - |
| CHEMBL5424303 | — | — | 1 | - |
| CHEMBL5401771 | — | — | 1 | - |
| CHEMBL5414625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL19980 | BREFELDIN A | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5420527 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5399866 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5403345 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5438677 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5398095 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5435512 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5428467 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5423886 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL5401692 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5428463 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL402341 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL5406439 | — | IC50 | = | 25190.0 | nM | 4.60 |
| CHEMBL5414388 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL5405850 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5416809 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5402975 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5402464 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5436861 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5423485 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5395276 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5397013 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5419421 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5407348 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5394303 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5412475 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5424303 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5401771 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5414625 | — | IC50 | > | 40000.0 | nM | - |