Assay Detail
Functional
CHEMBL5327792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.28 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430595 | — | — | 1 | 5.91 |
| CHEMBL5416468 | — | — | 1 | 5.68 |
| CHEMBL5423609 | — | — | 1 | 5.66 |
| CHEMBL5418544 | — | — | 1 | 5.64 |
| CHEMBL5439814 | — | — | 1 | 5.54 |
| CHEMBL5432047 | — | — | 1 | 5.51 |
| CHEMBL5428438 | — | — | 1 | 5.50 |
| CHEMBL5396537 | — | — | 1 | 5.49 |
| CHEMBL5439504 | — | — | 1 | 5.21 |
| CHEMBL1957266 | — | — | 1 | 5.21 |
| CHEMBL5426726 | — | — | 1 | 5.12 |
| CHEMBL5407507 | — | — | 1 | 5.09 |
| CHEMBL5412051 | — | — | 1 | 4.96 |
| CHEMBL5431994 | — | — | 1 | 4.93 |
| CHEMBL4532174 | — | — | 1 | 4.93 |
| CHEMBL5176169 | — | — | 1 | 4.93 |
| CHEMBL5431657 | — | — | 1 | 4.87 |
| CHEMBL5439456 | — | — | 1 | 4.81 |
| CHEMBL5440317 | — | — | 1 | - |
| CHEMBL5423622 | — | — | 1 | - |
| CHEMBL5405767 | — | — | 1 | - |
| CHEMBL5412012 | — | — | 1 | - |
| CHEMBL5418218 | — | — | 1 | - |
| CHEMBL5400425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430595 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5416468 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5423609 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL5418544 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5439814 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL5432047 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL5428438 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5396537 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5439504 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL1957266 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL5426726 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL5407507 | — | IC50 | = | 8090.0 | nM | 5.09 |
| CHEMBL5412051 | — | IC50 | = | 10880.0 | nM | 4.96 |
| CHEMBL5431994 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL4532174 | — | IC50 | = | 11650.0 | nM | 4.93 |
| CHEMBL5176169 | — | IC50 | = | 11680.0 | nM | 4.93 |
| CHEMBL5431657 | — | IC50 | = | 13470.0 | nM | 4.87 |
| CHEMBL5439456 | — | IC50 | = | 15390.0 | nM | 4.81 |
| CHEMBL5440317 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5423622 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5405767 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5412012 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5418218 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5400425 | — | IC50 | > | 20000.0 | nM | - |