Assay Detail
Binding
CHEMBL5327800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant PRC2 complex (unknown origin) incubated for 3 hrs in presence of SAM
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.62 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176169 | — | — | 1 | 7.05 |
| CHEMBL5416468 | — | — | 1 | 6.88 |
| CHEMBL5418544 | — | — | 1 | 6.74 |
| CHEMBL5396537 | — | — | 1 | 6.72 |
| CHEMBL5426726 | — | — | 1 | 6.42 |
| CHEMBL5439504 | — | — | 1 | 6.33 |
| CHEMBL5423609 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176169 | — | Kd | = | 89.1 | nM | 7.05 |
| CHEMBL5416468 | — | Kd | = | 133.0 | nM | 6.88 |
| CHEMBL5418544 | — | Kd | = | 180.5 | nM | 6.74 |
| CHEMBL5396537 | — | Kd | = | 190.2 | nM | 6.72 |
| CHEMBL5426726 | — | Kd | = | 376.2 | nM | 6.42 |
| CHEMBL5439504 | — | Kd | = | 463.5 | nM | 6.33 |
| CHEMBL5423609 | — | Kd | = | 682.3 | nM | 6.17 |