Assay Detail
Functional
CHEMBL5327941
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In vivo inhibition of JAK/STAT signaling pathway in mouse assessed as downregulation of IFN-gamma induced CXCL10 gene expression in whole blood treated sc followed by 24 hrs blood collected and measured by RT-PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.27 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430689 | — | — | 1 | 6.59 |
| CHEMBL5422616 | — | — | 1 | 6.46 |
| CHEMBL5418744 | — | — | 1 | 6.43 |
| CHEMBL5405569 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430689 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5422616 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL5418744 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL5405569 | — | IC50 | = | 2640.0 | nM | 5.58 |