Assay Detail
Binding
CHEMBL5327986
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Binding affinity to human JAK1 JH2 domain assessed as dissociation constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.39 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 9.48 |
| CHEMBL5422616 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | Kd | = | 0.33 | nM | 9.48 |
| CHEMBL5422616 | — | Kd | = | 4975.0 | nM | 5.30 |