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Assay Detail

CHEMBL5328005

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Binding
Inhibition of VEGFR2 (unknown origin)
ChEMBL ↗
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors.
Hou F, Yao Y, Wei Y, Wang Y, Cao Y, Liu X, Zheng L, Zhang Q, Jiao Y, Chen Y, Meng Y, Sun Y, Wu Y, Wang J, Wang J, Wu Z, Zhang K, Wei M, Yang G.
Bioorg Med Chem (2023) 91 : 117404 -117404
PubMed 37429211 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 8.78 9.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5411585 — — 1 9.96
CHEMBL5403470 — — 1 9.72
CHEMBL5410264 — — 1 9.59
CHEMBL5421802 — — 1 9.59
CHEMBL5425976 — — 1 9.49
CHEMBL5403747 — — 1 9.47
CHEMBL5400860 — — 1 9.44
CHEMBL5421149 — — 1 9.29
CHEMBL5407330 — — 1 9.29
CHEMBL5438830 — — 1 9.29
CHEMBL5412761 — — 1 9.26
CHEMBL5411025 — — 1 9.23
CHEMBL5393865 — — 1 9.18
CHEMBL5410108 — — 1 9.17
CHEMBL5394759 — — 1 9.15
CHEMBL5396911 — — 1 9.15
CHEMBL5405000 — — 1 9.13
CHEMBL5412144 — — 1 9.12
CHEMBL5414216 — — 1 9.03
CHEMBL5426431 — — 1 8.95
CHEMBL5408069 — — 1 8.94
CHEMBL5433332 — — 1 8.82
CHEMBL491473 CEDIRANIB 3.0 1 8.76
CHEMBL5432573 — — 1 8.73
CHEMBL5424131 — — 1 8.71
CHEMBL5409075 — — 1 8.61
CHEMBL5436823 — — 1 8.58
CHEMBL5414550 — — 1 8.56
CHEMBL5406253 — — 1 8.54
CHEMBL5406841 — — 1 8.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5411585 — IC50 = 0.11 nM 9.96
CHEMBL5403470 — IC50 = 0.19 nM 9.72
CHEMBL5421802 — IC50 = 0.26 nM 9.59
CHEMBL5410264 — IC50 = 0.26 nM 9.59
CHEMBL5425976 — IC50 = 0.32 nM 9.49
CHEMBL5403747 — IC50 = 0.34 nM 9.47
CHEMBL5400860 — IC50 = 0.36 nM 9.44
CHEMBL5421149 — IC50 = 0.51 nM 9.29
CHEMBL5407330 — IC50 = 0.51 nM 9.29
CHEMBL5438830 — IC50 = 0.51 nM 9.29
CHEMBL5412761 — IC50 = 0.55 nM 9.26
CHEMBL5411025 — IC50 = 0.59 nM 9.23
CHEMBL5393865 — IC50 = 0.66 nM 9.18
CHEMBL5410108 — IC50 = 0.67 nM 9.17
CHEMBL5396911 — IC50 = 0.7 nM 9.15
CHEMBL5394759 — IC50 = 0.71 nM 9.15
CHEMBL5405000 — IC50 = 0.74 nM 9.13
CHEMBL5412144 — IC50 = 0.76 nM 9.12
CHEMBL5414216 — IC50 = 0.93 nM 9.03
CHEMBL5426431 — IC50 = 1.13 nM 8.95
CHEMBL5408069 — IC50 = 1.15 nM 8.94
CHEMBL5433332 — IC50 = 1.5 nM 8.82
CHEMBL491473 CEDIRANIB IC50 = 1.72 nM 8.76
CHEMBL5432573 — IC50 = 1.85 nM 8.73
CHEMBL5424131 — IC50 = 1.95 nM 8.71
CHEMBL5409075 — IC50 = 2.44 nM 8.61
CHEMBL5436823 — IC50 = 2.65 nM 8.58
CHEMBL5414550 — IC50 = 2.74 nM 8.56
CHEMBL5406253 — IC50 = 2.92 nM 8.54
CHEMBL5406841 — IC50 = 2.96 nM 8.53
CHEMBL5401823 — IC50 = 3.27 nM 8.48
CHEMBL5419881 — IC50 = 3.88 nM 8.41
CHEMBL1946170 REGORAFENIB IC50 = 4.6 nM 8.34
CHEMBL5401089 — IC50 = 4.74 nM 8.32
CHEMBL5405595 — IC50 = 6.22 nM 8.21
CHEMBL5438648 — IC50 = 8.19 nM 8.09
CHEMBL5424340 — IC50 = 14.1 nM 7.85
CHEMBL5397253 — IC50 = 28.3 nM 7.55
CHEMBL5395547 — IC50 = 41.4 nM 7.38
CHEMBL5394767 — IC50 = 41.37 nM 7.38
CHEMBL5438351 — IC50 = 160.8 nM 6.79