Assay Detail
Binding
CHEMBL5328197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIK1 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated for 60 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase SIK1 (CHEMBL6082) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.23 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405960 | — | — | 1 | 8.14 |
| CHEMBL5426204 | — | — | 1 | 7.77 |
| CHEMBL5430450 | — | — | 1 | 7.66 |
| CHEMBL5394880 | — | — | 1 | 7.48 |
| CHEMBL5415835 | — | — | 1 | 7.19 |
| CHEMBL5407084 | — | — | 1 | 7.10 |
| CHEMBL5421558 | — | — | 1 | 7.06 |
| CHEMBL5415567 | — | — | 1 | 6.94 |
| CHEMBL5434195 | — | — | 1 | 6.73 |
| CHEMBL5393771 | — | — | 1 | 6.23 |
| CHEMBL5428308 | — | — | 1 | - |
| CHEMBL5420653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405960 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5426204 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5430450 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5394880 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5415835 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5407084 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5421558 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5415567 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5434195 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL5393771 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL5428308 | — | IC50 | - | — | - | |
| CHEMBL5420653 | — | IC50 | - | — | - |