Assay Detail
Functional
CHEMBL5328209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of IL-10 expression in human CD14+ monocytes isolated from PBMC measured incubated for 1 hr followed by LPS addition further incubated for 2 hrs by ELISA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.48 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394880 | — | — | 1 | 6.83 |
| CHEMBL5426204 | — | — | 1 | 6.58 |
| CHEMBL5430450 | — | — | 1 | 6.54 |
| CHEMBL5421558 | — | — | 1 | 6.49 |
| CHEMBL5393771 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394880 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL5426204 | — | EC50 | = | 265.0 | nM | 6.58 |
| CHEMBL5430450 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5421558 | — | EC50 | = | 327.0 | nM | 6.49 |
| CHEMBL5393771 | — | EC50 | = | 1087.0 | nM | 5.96 |