Assay Detail
Binding
CHEMBL5328252
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Binding affinity to FLAG-tagged human TIMP3 expressed in HEK293 cells assessed as dissociation constant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.45 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421682 | — | — | 1 | 9.07 |
| CHEMBL1207514 | — | — | 1 | 8.81 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 8.72 |
| CHEMBL1615557 | — | — | 1 | 8.33 |
| CHEMBL4300424 | — | — | 1 | 8.16 |
| CHEMBL1206126 | — | — | 1 | 7.58 |
| CHEMBL5420893 | — | — | 1 | - |
| CHEMBL5408018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421682 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL1207514 | — | Kd | = | 1.55 | nM | 8.81 |
| CHEMBL265502 | SURAMIN | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL1615557 | — | Kd | = | 4.66 | nM | 8.33 |
| CHEMBL4300424 | — | Kd | = | 6.88 | nM | 8.16 |
| CHEMBL1206126 | — | Kd | = | 26.5 | nM | 7.58 |
| CHEMBL5420893 | — | Kd | > | 100.0 | nM | - |
| CHEMBL5408018 | — | Kd | > | 100.0 | nM | - |