Assay Detail
Toxicity
CHEMBL5328400
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Cytotoxicity against anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as reduction in cell viability incubated for 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CD3-positive T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.93 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430021 | — | — | 1 | 6.33 |
| CHEMBL5441105 | — | — | 1 | 6.28 |
| CHEMBL5425004 | — | — | 1 | 6.28 |
| CHEMBL5412652 | — | — | 1 | 5.90 |
| CHEMBL5396693 | — | — | 1 | 5.72 |
| CHEMBL5439204 | — | — | 1 | 5.63 |
| CHEMBL5440958 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430021 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5441105 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL5425004 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5412652 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5396693 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5439204 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5440958 | — | IC50 | = | 4100.0 | nM | 5.39 |