Assay Detail
Functional
CHEMBL5328534
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Antiproliferative activity against human U266B1 cells assessed as cell growth inhibition incubated for 48 hrs by CCK8 colorimetric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-266 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.42 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5401559 | — | — | 1 | 6.58 |
| CHEMBL5439922 | — | — | 1 | 6.46 |
| CHEMBL5404231 | — | — | 1 | 6.39 |
| CHEMBL5412264 | — | — | 1 | 6.26 |
| CHEMBL5431842 | — | — | 1 | - |
| CHEMBL4856977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5401559 | — | IC50 | = | 264.8 | nM | 6.58 |
| CHEMBL5439922 | — | IC50 | = | 342.8 | nM | 6.46 |
| CHEMBL5404231 | — | IC50 | = | 407.3 | nM | 6.39 |
| CHEMBL5412264 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL5431842 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4856977 | — | IC50 | > | 1000.0 | nM | - |