Assay Detail
Binding
CHEMBL5328656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-labeled BI-FAMb from N-terminal His TEV-tagged human recombinant BRD9 bromodomain expressed in Escherichia coli BL21(DE3) by competitive fluorescence polarization assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.87 | 6.70 |
| Ki | 5 | 6.93 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823478 | — | — | 2 | 7.70 |
| CHEMBL5434122 | — | — | 2 | 6.89 |
| CHEMBL5413197 | — | — | 2 | 6.64 |
| CHEMBL5407972 | — | — | 2 | 6.47 |
| CHEMBL5412877 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823478 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5434122 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3823478 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5413197 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL5407972 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL5434122 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5413197 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5407972 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5412877 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5412877 | — | Ki | > | 20000.0 | nM | - |