Assay Detail
Functional
CHEMBL5328890
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Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.49 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407261 | — | — | 1 | 7.80 |
| CHEMBL5410666 | — | — | 1 | 7.28 |
| CHEMBL5431344 | — | — | 1 | 7.27 |
| CHEMBL5440334 | — | — | 1 | 7.08 |
| CHEMBL4793994 | — | — | 1 | 6.89 |
| CHEMBL5437073 | — | — | 1 | 6.76 |
| CHEMBL5397397 | — | — | 1 | 6.49 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.37 |
| CHEMBL5413310 | — | — | 1 | 6.32 |
| CHEMBL5408579 | — | — | 1 | 5.90 |
| CHEMBL5423373 | — | — | 1 | 5.63 |
| CHEMBL5429899 | — | — | 1 | 5.44 |
| CHEMBL5431847 | — | — | 1 | 5.11 |
| CHEMBL5397221 | — | — | 1 | - |
| CHEMBL5416032 | — | — | 1 | - |
| CHEMBL5419322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407261 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5410666 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5431344 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5440334 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4793994 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5437073 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5397397 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL5413310 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL5408579 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5423373 | — | IC50 | = | 2341.0 | nM | 5.63 |
| CHEMBL5429899 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL5431847 | — | IC50 | = | 7816.0 | nM | 5.11 |
| CHEMBL5397221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5416032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5419322 | — | IC50 | > | 10000.0 | nM | - |