Assay Detail
Binding
CHEMBL5329055
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Inhibition of JAK2 V617F mutant in mouse BaF3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.70 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422938 | — | — | 1 | 7.60 |
| CHEMBL4753549 | — | — | 1 | 7.39 |
| CHEMBL5419978 | — | — | 1 | 7.27 |
| CHEMBL5424098 | — | — | 1 | 7.16 |
| CHEMBL5408994 | — | — | 1 | 7.14 |
| CHEMBL5403283 | — | — | 1 | 7.06 |
| CHEMBL5440964 | — | — | 1 | 7.01 |
| CHEMBL5408539 | — | — | 1 | 7.00 |
| CHEMBL5432626 | — | — | 1 | 6.89 |
| CHEMBL5404973 | — | — | 1 | 6.77 |
| CHEMBL5437784 | — | — | 1 | 6.75 |
| CHEMBL5429688 | — | — | 1 | 6.74 |
| CHEMBL5436902 | — | — | 1 | 6.58 |
| CHEMBL5418281 | — | — | 1 | 6.43 |
| CHEMBL5416914 | — | — | 1 | 6.42 |
| CHEMBL5415635 | — | — | 1 | 6.06 |
| CHEMBL5398984 | — | — | 1 | 5.94 |
| CHEMBL5429799 | — | — | 1 | 5.66 |
| CHEMBL5416946 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422938 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4753549 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5419978 | — | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL5424098 | — | IC50 | = | 69.2 | nM | 7.16 |
| CHEMBL5408994 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5403283 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL5440964 | — | IC50 | = | 98.1 | nM | 7.01 |
| CHEMBL5408539 | — | IC50 | = | 101.1 | nM | 7.00 |
| CHEMBL5432626 | — | IC50 | = | 129.2 | nM | 6.89 |
| CHEMBL5404973 | — | IC50 | = | 169.5 | nM | 6.77 |
| CHEMBL5437784 | — | IC50 | = | 178.3 | nM | 6.75 |
| CHEMBL5429688 | — | IC50 | = | 182.4 | nM | 6.74 |
| CHEMBL5436902 | — | IC50 | = | 265.5 | nM | 6.58 |
| CHEMBL5418281 | — | IC50 | = | 371.9 | nM | 6.43 |
| CHEMBL5416914 | — | IC50 | = | 384.6 | nM | 6.42 |
| CHEMBL5415635 | — | IC50 | = | 869.5 | nM | 6.06 |
| CHEMBL5398984 | — | IC50 | = | 1139.5 | nM | 5.94 |
| CHEMBL5429799 | — | IC50 | = | 2204.4 | nM | 5.66 |
| CHEMBL5416946 | — | IC50 | = | 3314.5 | nM | 5.48 |