Assay Detail
Binding
CHEMBL5329056
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Inhibition of FLT3 in human MOLM-13 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of <i>N</i>-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.85 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422938 | — | — | 1 | 6.24 |
| CHEMBL5403283 | — | — | 1 | 6.12 |
| CHEMBL5436902 | — | — | 1 | 6.08 |
| CHEMBL5408539 | — | — | 1 | 6.05 |
| CHEMBL5437784 | — | — | 1 | 6.05 |
| CHEMBL5440964 | — | — | 1 | 6.02 |
| CHEMBL5419978 | — | — | 1 | 5.90 |
| CHEMBL5408994 | — | — | 1 | 5.89 |
| CHEMBL5424098 | — | — | 1 | 5.82 |
| CHEMBL5429688 | — | — | 1 | 5.78 |
| CHEMBL5418281 | — | — | 1 | 5.78 |
| CHEMBL5432626 | — | — | 1 | 5.75 |
| CHEMBL5404973 | — | — | 1 | 5.75 |
| CHEMBL5416914 | — | — | 1 | 5.25 |
| CHEMBL5415635 | — | — | 1 | 5.23 |
| CHEMBL5398984 | — | — | 1 | - |
| CHEMBL5416946 | — | — | 1 | - |
| CHEMBL5429799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422938 | — | IC50 | = | 582.6 | nM | 6.24 |
| CHEMBL5403283 | — | IC50 | = | 755.7 | nM | 6.12 |
| CHEMBL5436902 | — | IC50 | = | 825.6 | nM | 6.08 |
| CHEMBL5408539 | — | IC50 | = | 885.4 | nM | 6.05 |
| CHEMBL5437784 | — | IC50 | = | 882.4 | nM | 6.05 |
| CHEMBL5440964 | — | IC50 | = | 961.2 | nM | 6.02 |
| CHEMBL5419978 | — | IC50 | = | 1254.1 | nM | 5.90 |
| CHEMBL5408994 | — | IC50 | = | 1276.5 | nM | 5.89 |
| CHEMBL5424098 | — | IC50 | = | 1505.7 | nM | 5.82 |
| CHEMBL5429688 | — | IC50 | = | 1665.4 | nM | 5.78 |
| CHEMBL5418281 | — | IC50 | = | 1676.2 | nM | 5.78 |
| CHEMBL5432626 | — | IC50 | = | 1760.2 | nM | 5.75 |
| CHEMBL5404973 | — | IC50 | = | 1796.7 | nM | 5.75 |
| CHEMBL5416914 | — | IC50 | = | 5560.4 | nM | 5.25 |
| CHEMBL5415635 | — | IC50 | = | 5843.6 | nM | 5.23 |
| CHEMBL5398984 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL5416946 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL5429799 | — | IC50 | > | 10.0 | nM | - |