Assay Detail
Binding
CHEMBL5329059
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Inhibition of JAK1 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.03 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753549 | — | — | 1 | 7.38 |
| CHEMBL5403283 | — | — | 1 | 7.37 |
| CHEMBL5440964 | — | — | 1 | 7.14 |
| CHEMBL5408994 | — | — | 1 | 7.06 |
| CHEMBL5432626 | — | — | 1 | 6.97 |
| CHEMBL5424098 | — | — | 1 | 6.85 |
| CHEMBL5419978 | — | — | 1 | 6.75 |
| CHEMBL5422938 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753549 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5403283 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5440964 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5408994 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5432626 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5424098 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5419978 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5422938 | — | IC50 | = | 193.0 | nM | 6.71 |