Assay Detail
Functional
CHEMBL5329533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against CHO 51D1 cells with Rad51d knockout assessed as reduction in cell proliferation incubated for 5 days by sulforhodamine B assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO 51D1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.44 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 9.38 |
| CHEMBL5403789 | — | — | 1 | 8.40 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 7.66 |
| CHEMBL5411944 | — | — | 1 | 6.86 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 6.26 |
| CHEMBL5403607 | — | — | 1 | 5.88 |
| CHEMBL5405947 | — | — | 1 | 4.59 |
| CHEMBL5440303 | — | — | 1 | 4.49 |
| CHEMBL5434068 | — | — | 1 | 4.47 |
| CHEMBL5431934 | — | — | 1 | - |
| CHEMBL5430669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 0.417 | nM | 9.38 |
| CHEMBL5403789 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5411944 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5403607 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5405947 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL5440303 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL5434068 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL5431934 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL5430669 | — | IC50 | = | 158000.0 | nM | - |