Assay Detail
ADMET
CHEMBL5329969
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Inhibition of human CYP11B2 stably transfected in mouse Y-1 cells using deoxycortisol or deoxycorticosterone as substrate incubated for 48 hrs by radioimmuno assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Y-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 7.84 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406728 | — | — | 1 | 9.52 |
| CHEMBL5439285 | — | — | 1 | 9.12 |
| CHEMBL5396904 | — | — | 1 | 9.03 |
| CHEMBL5418063 | — | — | 1 | 9.03 |
| CHEMBL5413320 | — | — | 1 | 9.00 |
| CHEMBL5400111 | — | — | 1 | 8.82 |
| CHEMBL5402622 | — | — | 1 | 8.80 |
| CHEMBL5415328 | — | — | 1 | 8.77 |
| CHEMBL5408774 | — | — | 1 | 8.66 |
| CHEMBL5424502 | — | — | 1 | 8.60 |
| CHEMBL5409957 | — | — | 1 | 8.59 |
| CHEMBL5413659 | — | — | 1 | 8.54 |
| CHEMBL5412612 | — | — | 1 | 8.42 |
| CHEMBL5417708 | — | — | 1 | 8.38 |
| CHEMBL5408597 | — | — | 1 | 8.34 |
| CHEMBL5397427 | — | — | 1 | 8.34 |
| CHEMBL5415158 | — | — | 1 | 8.34 |
| CHEMBL5398781 | — | — | 1 | 8.19 |
| CHEMBL5401923 | — | — | 1 | 8.14 |
| CHEMBL5424651 | — | — | 1 | 8.14 |
| CHEMBL5431649 | — | — | 1 | 8.12 |
| CHEMBL5438181 | — | — | 1 | 8.06 |
| CHEMBL5405763 | — | — | 1 | 8.02 |
| CHEMBL5426685 | — | — | 1 | 8.00 |
| CHEMBL5394924 | — | — | 1 | 7.98 |
| CHEMBL5420175 | — | — | 1 | 7.95 |
| CHEMBL5433146 | — | — | 1 | 7.93 |
| CHEMBL5405085 | — | — | 1 | 7.92 |
| CHEMBL5432000 | — | — | 1 | 7.90 |
| CHEMBL5393932 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406728 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5439285 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5418063 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL5396904 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL5413320 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5400111 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5402622 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5415328 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5408774 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5424502 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5409957 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5413659 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5412612 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5417708 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5415158 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5397427 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5408597 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5398781 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5401923 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5424651 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5431649 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5438181 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5405763 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5426685 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5394924 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL5420175 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5433146 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5405085 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5432000 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5393932 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5416314 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL5414558 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5415822 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5437875 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5420707 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5410140 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL5424888 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL5430478 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL5415836 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL5410752 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5423538 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5412539 | — | IC50 | = | 47.6 | nM | 7.32 |
| CHEMBL5396271 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL5407517 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5426410 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5409569 | — | IC50 | = | 90.4 | nM | 7.04 |
| CHEMBL5420100 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5418651 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5431476 | — | IC50 | = | 142.0 | nM | 6.85 |