Assay Detail
ADMET
CHEMBL5329972
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Inhibition of human CYP11B2 expressed in human NCI-H295 cells incubated for 48 hrs by radioimmuno assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H295 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.17 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5402622 | — | — | 1 | 8.96 |
| CHEMBL5413320 | — | — | 1 | 8.96 |
| CHEMBL5409957 | — | — | 1 | 8.72 |
| CHEMBL5417708 | — | — | 1 | 8.64 |
| CHEMBL5414558 | — | — | 1 | 8.47 |
| CHEMBL5408597 | — | — | 1 | 8.42 |
| CHEMBL5438181 | — | — | 1 | 8.24 |
| CHEMBL5413659 | — | — | 1 | 8.21 |
| CHEMBL5426685 | — | — | 1 | 8.17 |
| CHEMBL5418063 | — | — | 1 | 8.12 |
| CHEMBL5412612 | — | — | 1 | 8.07 |
| CHEMBL5405763 | — | — | 1 | 7.97 |
| CHEMBL5401923 | — | — | 1 | 7.96 |
| CHEMBL5398781 | — | — | 1 | 7.96 |
| CHEMBL5405085 | — | — | 1 | 7.94 |
| CHEMBL5410140 | — | — | 1 | 7.78 |
| CHEMBL5420707 | — | — | 1 | 7.64 |
| CHEMBL5400111 | — | — | 1 | 7.61 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5402622 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5413320 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5409957 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5417708 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5414558 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5408597 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5438181 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5413659 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5426685 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5418063 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5412612 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5405763 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL5401923 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5398781 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL5405085 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5410140 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5420707 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL5400111 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 50.1 | nM | 7.30 |