Assay Detail
Binding
CHEMBL5330087
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Inhibition of SREBP/SCAP (unknown origin) transfected with CHO-K1 cells cotransfected with pSRE-Luc/pAC-beta-gal measured after 24 hrs by Steady-Glo luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.67 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426077 | — | — | 1 | 5.85 |
| CHEMBL5404026 | — | — | 1 | 5.70 |
| CHEMBL4851466 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426077 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5404026 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4851466 | — | IC50 | = | 3500.0 | nM | 5.46 |