Assay Detail
Functional
CHEMBL5330117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as reduction in promastigotes viability incubated for 24 hrs by resazurin-based alamar blue dye assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3,3'-diindolylmethane <i>N</i>-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.48 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.40 |
| CHEMBL5399612 | — | — | 1 | 4.55 |
| CHEMBL5402248 | — | — | 1 | 4.54 |
| CHEMBL5433565 | — | — | 1 | 4.50 |
| CHEMBL2430211 | — | — | 1 | 4.46 |
| CHEMBL4100585 | — | — | 1 | 4.44 |
| CHEMBL2430212 | — | — | 1 | 4.38 |
| CHEMBL4067396 | — | — | 1 | 4.33 |
| CHEMBL2430214 | — | — | 1 | 4.32 |
| CHEMBL5424543 | — | — | 1 | 4.32 |
| CHEMBL5413802 | — | — | 1 | 4.27 |
| CHEMBL2376692 | — | — | 1 | 4.26 |
| CHEMBL574338 | — | — | 1 | 4.26 |
| CHEMBL2376559 | — | — | 1 | 4.24 |
| CHEMBL576177 | — | — | 1 | 4.23 |
| CHEMBL5419558 | — | — | 1 | 4.13 |
| CHEMBL2430213 | — | — | 1 | - |
| CHEMBL5439974 | — | — | 1 | - |
| CHEMBL1983199 | — | — | 1 | - |
| CHEMBL3237337 | — | — | 1 | - |
| CHEMBL5438663 | — | — | 1 | - |
| CHEMBL1995195 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5399612 | — | IC50 | = | 27910.0 | nM | 4.55 |
| CHEMBL5402248 | — | IC50 | = | 29110.0 | nM | 4.54 |
| CHEMBL5433565 | — | IC50 | = | 31380.0 | nM | 4.50 |
| CHEMBL2430211 | — | IC50 | = | 34810.0 | nM | 4.46 |
| CHEMBL4100585 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL2430212 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL4067396 | — | IC50 | = | 46980.0 | nM | 4.33 |
| CHEMBL2430214 | — | IC50 | = | 48470.0 | nM | 4.32 |
| CHEMBL5424543 | — | IC50 | = | 48350.0 | nM | 4.32 |
| CHEMBL5413802 | — | IC50 | = | 53190.0 | nM | 4.27 |
| CHEMBL2376692 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL574338 | — | IC50 | = | 54290.0 | nM | 4.26 |
| CHEMBL2376559 | — | IC50 | = | 57120.0 | nM | 4.24 |
| CHEMBL576177 | — | IC50 | = | 59200.0 | nM | 4.23 |
| CHEMBL5419558 | — | IC50 | = | 74270.0 | nM | 4.13 |
| CHEMBL2430213 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5439974 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1983199 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3237337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5438663 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1995195 | — | IC50 | > | 100000.0 | nM | - |