Assay Detail
Functional
CHEMBL5330156
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Antileishmanial activity against Leishmania infantum axenic amastigotes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the 2-arylquinazoline-4(3<i>H</i>)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397544 | — | — | 1 | 6.05 |
| CHEMBL5434485 | — | — | 1 | 6.03 |
| CHEMBL5408126 | — | — | 1 | 5.45 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.06 |
| CHEMBL5407773 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397544 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5434485 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5408126 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL5407773 | — | IC50 | = | 11120.0 | nM | 4.95 |