Assay Detail
Functional
CHEMBL5330158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania infantum promastigotes in presence of FA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the 2-arylquinazoline-4(3<i>H</i>)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.37 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431637 | — | — | 1 | 5.69 |
| CHEMBL5436408 | — | — | 1 | 5.55 |
| CHEMBL1163173 | — | — | 1 | 5.21 |
| CHEMBL18688 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431637 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5436408 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL1163173 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL18688 | — | IC50 | = | 9780.0 | nM | 5.01 |