Assay Detail
Functional
CHEMBL5330475
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Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New aryl-/heteroarylpiperazine derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5,10-trione: Synthesis and preliminary studies of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.43 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.68 |
| CHEMBL5435378 | — | — | 1 | 5.40 |
| CHEMBL5409943 | — | — | 1 | 5.36 |
| CHEMBL5395179 | — | — | 1 | 5.25 |
| CHEMBL5422403 | — | — | 1 | 5.17 |
| CHEMBL5403228 | — | — | 1 | 5.09 |
| CHEMBL5437394 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5435378 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL5409943 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL5395179 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL5422403 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL5403228 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL5437394 | — | IC50 | = | 8860.0 | nM | 5.05 |