Assay Detail
Functional
CHEMBL5330478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SW620 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New aryl-/heteroarylpiperazine derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5,10-trione: Synthesis and preliminary studies of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.18 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.58 |
| CHEMBL5422403 | — | — | 1 | 5.32 |
| CHEMBL5435378 | — | — | 1 | 5.21 |
| CHEMBL5403228 | — | — | 1 | 4.87 |
| CHEMBL5437394 | — | — | 1 | 4.80 |
| CHEMBL5409943 | — | — | 1 | 4.80 |
| CHEMBL5395179 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5422403 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5435378 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5403228 | — | IC50 | = | 13510.0 | nM | 4.87 |
| CHEMBL5437394 | — | IC50 | = | 15990.0 | nM | 4.80 |
| CHEMBL5409943 | — | IC50 | = | 15930.0 | nM | 4.80 |
| CHEMBL5395179 | — | IC50 | = | 22390.0 | nM | 4.65 |