Assay Detail
Toxicity
CHEMBL5330482
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Cytotoxicity against human HMEC-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HMEC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New aryl-/heteroarylpiperazine derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5,10-trione: Synthesis and preliminary studies of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.84 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.30 |
| CHEMBL5395179 | — | — | 1 | 4.75 |
| CHEMBL5435378 | — | — | 1 | 4.68 |
| CHEMBL5409943 | — | — | 1 | 4.66 |
| CHEMBL5422403 | — | — | 1 | 4.52 |
| CHEMBL5403228 | — | — | 1 | 4.51 |
| CHEMBL5437394 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5395179 | — | IC50 | = | 17690.0 | nM | 4.75 |
| CHEMBL5435378 | — | IC50 | = | 20640.0 | nM | 4.68 |
| CHEMBL5409943 | — | IC50 | = | 21930.0 | nM | 4.66 |
| CHEMBL5422403 | — | IC50 | = | 30220.0 | nM | 4.52 |
| CHEMBL5403228 | — | IC50 | = | 30540.0 | nM | 4.51 |
| CHEMBL5437394 | — | IC50 | = | 36580.0 | nM | 4.44 |