Assay Detail
Binding
CHEMBL5330630
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Inhibition of FAK (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of diaminopyrimidine derivatives as novel focal adhesion kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4742157 | GSK-2256098 | 2.0 | 1 | 9.40 |
| CHEMBL3137331 | DEFACTINIB | 3.0 | 1 | 9.22 |
| CHEMBL3657311 | IFEBEMTINIB | 2.0 | 1 | 9.00 |
| CHEMBL458997 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4742157 | GSK-2256098 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3137331 | DEFACTINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3657311 | IFEBEMTINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL458997 | — | IC50 | = | 5.5 | nM | 8.26 |