Assay Detail
Functional
CHEMBL5330668
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Antiviral activity against HBV infected human HePAD38 cells assessed as reduction of HBV DNA level with compound replacement for every 3 days and measured on day 6 by qPCR analysis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HePAD38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 6.08 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3742114 | — | — | 1 | 8.15 |
| CHEMBL5407234 | — | — | 1 | 7.70 |
| CHEMBL5427684 | — | — | 1 | 7.68 |
| CHEMBL5439367 | — | — | 1 | 7.36 |
| CHEMBL5410105 | — | — | 1 | 7.16 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.05 |
| CHEMBL5432999 | — | — | 1 | 6.41 |
| CHEMBL5432115 | — | — | 1 | 6.34 |
| CHEMBL5435389 | — | — | 1 | 6.30 |
| CHEMBL5408139 | — | — | 1 | 6.24 |
| CHEMBL5424904 | — | — | 1 | 6.08 |
| CHEMBL5428939 | — | — | 1 | 6.07 |
| CHEMBL5421360 | — | — | 1 | 5.91 |
| CHEMBL5424213 | — | — | 1 | 5.64 |
| CHEMBL5423022 | — | — | 1 | 5.63 |
| CHEMBL5431919 | — | — | 1 | 5.62 |
| CHEMBL5399901 | — | — | 1 | 5.61 |
| CHEMBL5434638 | — | — | 1 | 5.60 |
| CHEMBL5396233 | — | — | 1 | 5.57 |
| CHEMBL5412449 | — | — | 1 | 5.42 |
| CHEMBL5406756 | — | — | 1 | 5.41 |
| CHEMBL5424974 | — | — | 1 | 5.37 |
| CHEMBL5425826 | — | — | 1 | 5.27 |
| CHEMBL5437520 | — | — | 1 | 5.20 |
| CHEMBL5430382 | — | — | 1 | 5.19 |
| CHEMBL5413703 | — | — | 1 | 5.07 |
| CHEMBL5435155 | — | — | 1 | 5.00 |
| CHEMBL5416614 | — | — | 1 | - |
| CHEMBL5421400 | — | — | 1 | - |
| CHEMBL5439893 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3742114 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5407234 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5427684 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5439367 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5410105 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5432999 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5432115 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5435389 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5408139 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5424904 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5428939 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5421360 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5424213 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5423022 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5431919 | — | EC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5399901 | — | EC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL5434638 | — | EC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL5396233 | — | EC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL5412449 | — | EC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL5406756 | — | EC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL5424974 | — | EC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5425826 | — | EC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL5437520 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5430382 | — | EC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL5413703 | — | EC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL5435155 | — | EC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL5401554 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5398798 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5433598 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5407414 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5394072 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5397477 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5439893 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5421400 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5416614 | — | EC50 | > | 10000.0 | nM | - |