Assay Detail
Functional
CHEMBL5331005
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.18 | 7.00 |
| GI | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414116 | — | — | 1 | 7.00 |
| CHEMBL5399372 | — | — | 1 | 6.80 |
| CHEMBL5419328 | — | — | 1 | 6.00 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 5.70 |
| CHEMBL5417466 | — | — | 1 | 5.55 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.46 |
| CHEMBL5395601 | — | — | 1 | 5.39 |
| CHEMBL5413601 | — | — | 1 | 5.28 |
| CHEMBL5399841 | — | — | 1 | 5.19 |
| CHEMBL5425754 | — | — | 1 | 5.19 |
| CHEMBL5405427 | — | — | 1 | 5.07 |
| CHEMBL5396168 | — | — | 1 | 5.04 |
| CHEMBL5412035 | — | — | 1 | 4.98 |
| CHEMBL5417440 | — | — | 1 | 4.95 |
| CHEMBL5419604 | — | — | 1 | 4.90 |
| CHEMBL5401822 | — | — | 1 | 4.90 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.82 |
| CHEMBL5412907 | — | — | 1 | 4.81 |
| CHEMBL5432334 | — | — | 1 | 4.80 |
| CHEMBL5396771 | — | — | 1 | 4.76 |
| CHEMBL5418133 | — | — | 1 | 4.75 |
| CHEMBL5423587 | — | — | 1 | 4.71 |
| CHEMBL5399139 | — | — | 1 | 4.69 |
| CHEMBL5425197 | — | — | 1 | 4.62 |
| CHEMBL5432723 | — | — | 1 | 4.25 |
| CHEMBL5403733 | — | — | 1 | - |
| CHEMBL5440123 | — | — | 1 | - |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414116 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5399372 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5419328 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5417466 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5395601 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5413601 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5399841 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5425754 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5405427 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL5396168 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5412035 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5417440 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL5419604 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL5401822 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL5412907 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5432334 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5396771 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5418133 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL5423587 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5399139 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL5425197 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5432723 | — | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL5403733 | — | IC50 | = | 170900.0 | nM | - |
| CHEMBL5440123 | — | GI | - | — | - | |
| CHEMBL1580 | PENTOSTATIN | GI | - | — | - |