Assay Detail
Functional
CHEMBL5331012
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Cytotoxicity against human SNU-182 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-182 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.54 | 5.22 |
| GI | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414116 | — | — | 1 | 5.22 |
| CHEMBL5395601 | — | — | 1 | 4.91 |
| CHEMBL5401822 | — | — | 1 | 4.91 |
| CHEMBL5419328 | — | — | 1 | 4.89 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 4.63 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.43 |
| CHEMBL5396168 | — | — | 1 | 4.39 |
| CHEMBL5413601 | — | — | 1 | 4.32 |
| CHEMBL5399841 | — | — | 1 | 4.22 |
| CHEMBL5425754 | — | — | 1 | 4.21 |
| CHEMBL5399372 | — | — | 1 | 4.19 |
| CHEMBL5417466 | — | — | 1 | 4.19 |
| CHEMBL5405427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414116 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5395601 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5401822 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5419328 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL5396168 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5413601 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL5399841 | — | IC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL5425754 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL5399372 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5417466 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5405427 | — | GI | - | — | - |