Assay Detail
Functional
CHEMBL5331013
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Cytotoxicity against human SNU-387 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-387 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.84 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395601 | — | — | 1 | 5.70 |
| CHEMBL5401822 | — | — | 1 | 5.70 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 5.15 |
| CHEMBL5413601 | — | — | 1 | 4.96 |
| CHEMBL5414116 | — | — | 1 | 4.89 |
| CHEMBL5399841 | — | — | 1 | 4.80 |
| CHEMBL5405427 | — | — | 1 | 4.80 |
| CHEMBL5399372 | — | — | 1 | 4.70 |
| CHEMBL5417466 | — | — | 1 | 4.70 |
| CHEMBL5396168 | — | — | 1 | 4.58 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.47 |
| CHEMBL5419328 | — | — | 1 | 4.42 |
| CHEMBL5425754 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395601 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5401822 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5413601 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5414116 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5399841 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5405427 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5399372 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5417466 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5396168 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL5419328 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5425754 | — | IC50 | = | 88000.0 | nM | 4.06 |