Assay Detail
Functional
CHEMBL5331015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SNU-423 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-423 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.00 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395601 | — | — | 1 | 5.40 |
| CHEMBL5401822 | — | — | 1 | 5.40 |
| CHEMBL5405427 | — | — | 1 | 5.17 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 5.17 |
| CHEMBL5413601 | — | — | 1 | 5.02 |
| CHEMBL5399372 | — | — | 1 | 5.00 |
| CHEMBL5417466 | — | — | 1 | 5.00 |
| CHEMBL5399841 | — | — | 1 | 4.98 |
| CHEMBL5414116 | — | — | 1 | 4.96 |
| CHEMBL5419328 | — | — | 1 | 4.82 |
| CHEMBL5396168 | — | — | 1 | 4.80 |
| CHEMBL5425754 | — | — | 1 | 4.76 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395601 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5401822 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5405427 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5413601 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5399372 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5417466 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5399841 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5414116 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5419328 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5396168 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5425754 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 32600.0 | nM | 4.49 |