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Assay Detail

CHEMBL5331243

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IMP1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.
Li R, Chen X, Zhou C, Dai QQ, Yang L.
Eur J Med Chem (2022) 242 : 114677 -114677
PubMed 35988449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.08 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5404362 1 9.80
CHEMBL5408399 1 9.24
CHEMBL5415874 1 9.20
CHEMBL5428850 1 8.50
CHEMBL4177035 1 7.39
CHEMBL3577963 1 5.92
CHEMBL5417591 1 5.54
CHEMBL4169182 1 5.40
CHEMBL434965 D-CAPTOPRIL 1 5.14
CHEMBL1560 CAPTOPRIL 4.0 1 4.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5404362 IC50 = 0.16 nM 9.80
CHEMBL5408399 IC50 = 0.58 nM 9.24
CHEMBL5415874 IC50 = 0.631 nM 9.20
CHEMBL5428850 IC50 = 3.162 nM 8.50
CHEMBL4177035 IC50 = 41.0 nM 7.39
CHEMBL3577963 IC50 = 1200.0 nM 5.92
CHEMBL5417591 IC50 = 2900.0 nM 5.54
CHEMBL4169182 IC50 = 3980.0 nM 5.40
CHEMBL434965 D-CAPTOPRIL IC50 = 7200.0 nM 5.14
CHEMBL1560 CAPTOPRIL IC50 = 23300.0 nM 4.63