Assay Detail

CHEMBL5331295

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of Escherichia coli beta-lactamase CMY-2

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.

Li R, Chen X, Zhou C, Dai QQ, Yang L.
Eur J Med Chem (2022) 242 : 114677 -114677
PubMed 35988449 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.59	7.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3989959	NACUBACTAM	3.0	1	7.82
CHEMBL1689063	AVIBACTAM	4.0	1	7.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3989959	NACUBACTAM	IC50	=	15.0	nM	7.82
CHEMBL1689063	AVIBACTAM	IC50	=	44.0	nM	7.36