Assay Detail

CHEMBL5331301

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Binding

Inhibition of Escherichia coli beta-lactamase TEM-1

ChEMBL ↗

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Target

Beta-lactamase TEM-1 (CHEMBL1287599) ↗

Open DB target context

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Beta-lactamase TEM-1 (CHEMBL1287599) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-lactamase TEM-1

CHEMBL1287599

Anchored from Assay target.

Protein identity Beta-lactamase TEM-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-lactamase TEM-1 (CHEMBL1287599) ↗

Type	SINGLE PROTEIN
Organism	Escherichia coli

Publication

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.

Li R, Chen X, Zhou C, Dai QQ, Yang L.
Eur J Med Chem (2022) 242 : 114677 -114677
PubMed 35988449 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.87	8.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1689063	AVIBACTAM	4.0	1	8.15
CHEMBL3989959	NACUBACTAM	3.0	1	7.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1689063	AVIBACTAM	IC50	=	7.0	nM	8.15
CHEMBL3989959	NACUBACTAM	IC50	=	26.0	nM	7.58