Assay Detail
Binding
CHEMBL5331907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HIV-1 LEDGF-dependent full length His-tagged integrase expressed in Escherichia coli BL21 (DE3) by HTRF method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.38 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377937 | KUWANON L | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377937 | KUWANON L | IC50 | = | 42000.0 | nM | 4.38 |